Your browser doesn't support javascript.
loading
Triggering bilayer to inverted-hexagonal nanostructure formation by thiol-ene click chemistry on cationic lipids: consequences on gene transfection.
Afonso, Damien; Le Gall, Tony; Couthon-Gourvès, Hélène; Grélard, Axelle; Prakash, Shipra; Berchel, Mathieu; Kervarec, Nelly; Dufourc, Erick J; Montier, Tristan; Jaffrès, Paul-Alain.
Affiliation
  • Afonso D; CEMCA CNRS UMR 6521, plateforme de RMN RPE MS, Université de Brest, IBSAM, 6 Avenue V. Le Gorgeu, 29238 Brest, France. pjaffres@univ-brest.fr.
  • Le Gall T; INSERM U1078, Université de Brest, IBSAM, Faculté de Médecine et des sciences de la santé, 22 avenue Camille Desmoulins, 29238 Brest Cedex 3, France.
  • Couthon-Gourvès H; CEMCA CNRS UMR 6521, plateforme de RMN RPE MS, Université de Brest, IBSAM, 6 Avenue V. Le Gorgeu, 29238 Brest, France. pjaffres@univ-brest.fr.
  • Grélard A; Institute of Chemistry & Biology of Membranes & Nano-objects, CBMN, UMR CNRS 5248, University of Bordeaux, Bordeaux INP, Allée Geoffroy de St Hilaire, F-33600 Pessac, France.
  • Prakash S; Institute of Chemistry & Biology of Membranes & Nano-objects, CBMN, UMR CNRS 5248, University of Bordeaux, Bordeaux INP, Allée Geoffroy de St Hilaire, F-33600 Pessac, France.
  • Berchel M; CEMCA CNRS UMR 6521, plateforme de RMN RPE MS, Université de Brest, IBSAM, 6 Avenue V. Le Gorgeu, 29238 Brest, France. pjaffres@univ-brest.fr.
  • Kervarec N; CEMCA CNRS UMR 6521, plateforme de RMN RPE MS, Université de Brest, IBSAM, 6 Avenue V. Le Gorgeu, 29238 Brest, France. pjaffres@univ-brest.fr.
  • Dufourc EJ; Institute of Chemistry & Biology of Membranes & Nano-objects, CBMN, UMR CNRS 5248, University of Bordeaux, Bordeaux INP, Allée Geoffroy de St Hilaire, F-33600 Pessac, France.
  • Montier T; INSERM U1078, Université de Brest, IBSAM, Faculté de Médecine et des sciences de la santé, 22 avenue Camille Desmoulins, 29238 Brest Cedex 3, France and CHRU de Brest, Hôpital Morvan, 5 avenue du maréchal Foch, 29609 Brest cedex, France and DUMG, Faculté de Médecine et des Sciences de la Santé, 22 a
  • Jaffrès PA; CEMCA CNRS UMR 6521, plateforme de RMN RPE MS, Université de Brest, IBSAM, 6 Avenue V. Le Gorgeu, 29238 Brest, France. pjaffres@univ-brest.fr.
Soft Matter ; 12(20): 4516-20, 2016 05 18.
Article in En | MEDLINE | ID: mdl-27146355
The ramification of cationic amphiphiles on their unsaturated lipid chains is readily achieved by using the thiol-ene click reaction triggering the formation of an inverted hexagonal phase (HII). The new ramified cationic lipids exhibit different bio-activities (transfection, toxicity) including higher transfection efficacies on 16HBE 14o-cell lines.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfhydryl Compounds / Drug Carriers / Transfection / Nanostructures / Alkenes / Lipids Language: En Journal: Soft Matter Year: 2016 Type: Article Affiliation country: France
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfhydryl Compounds / Drug Carriers / Transfection / Nanostructures / Alkenes / Lipids Language: En Journal: Soft Matter Year: 2016 Type: Article Affiliation country: France