Roles of RNA-binding Proteins and Post-transcriptional Regulation in Driving Male Germ Cell Development in the Mouse.
Adv Exp Med Biol
; 907: 123-51, 2016.
Article
in En
| MEDLINE
| ID: mdl-27256385
ABSTRACT
Tissue development and homeostasis are dependent on highly regulated gene expression programs in which cell-specific combinations of regulatory factors determine which genes are expressed and the post-transcriptional fate of the resulting RNA transcripts. Post-transcriptional regulation of gene expression by RNA-binding proteins has critical roles in tissue development-allowing individual genes to generate multiple RNA and protein products, and the timing, location, and abundance of protein synthesis to be finely controlled. Extensive post-transcriptional regulation occurs during mammalian gametogenesis, including high levels of alternative mRNA expression, stage-specific expression of mRNA variants, broad translational repression, and stage-specific activation of mRNA translation. In this chapter, an overview of the roles of RNA-binding proteins and the importance of post-transcriptional regulation in male germ cell development in the mouse is presented.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spermatogenesis
/
RNA
/
RNA Processing, Post-Transcriptional
/
RNA-Binding Proteins
/
Gene Expression Regulation, Developmental
/
Germ Cells
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Adv Exp Med Biol
Year:
2016
Type:
Article
Affiliation country:
United States