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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.
Gotter, Anthony L; Forman, Mark S; Harrell, Charles M; Stevens, Joanne; Svetnik, Vladimir; Yee, Ka Lai; Li, Xiaodong; Roecker, Anthony J; Fox, Steven V; Tannenbaum, Pamela L; Garson, Susan L; Lepeleire, Inge De; Calder, Nicole; Rosen, Laura; Struyk, Arie; Coleman, Paul J; Herring, W Joseph; Renger, John J; Winrow, Christopher J.
Affiliation
  • Gotter AL; Department of Neuroscience, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Forman MS; Department of Translational Medicine, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Harrell CM; Department of Neuroscience, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Stevens J; Department of in vivo Pharmacology, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Svetnik V; Department of Biostatistics and Research Decision Sciences, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Yee KL; Department of Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Li X; Department of Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Roecker AJ; Department of Medicinal Chemistry, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Fox SV; Department of in vivo Pharmacology, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Tannenbaum PL; Department of in vivo Pharmacology, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Garson SL; Department of Neuroscience, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Lepeleire ID; Department of Translational Medicine, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Calder N; Department of Clinical Neuroscience, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Rosen L; Department of Clinical Neuroscience, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Struyk A; Department of Translational Medicine, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Coleman PJ; Department of Medicinal Chemistry, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Herring WJ; Department of Clinical Neuroscience, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Renger JJ; Department of Neuroscience, Merck &Co. Inc., Kenilworth, NJ, USA.
  • Winrow CJ; Department of Neuroscience, Merck &Co. Inc., Kenilworth, NJ, USA.
Sci Rep ; 6: 27147, 2016 06 03.
Article in En | MEDLINE | ID: mdl-27256922
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sleep Stages / Orexin Receptors / Orexin Receptor Antagonists / Sleep Aids, Pharmaceutical Type of study: Clinical_trials Limits: Animals / Female / Humans / Male Language: En Journal: Sci Rep Year: 2016 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sleep Stages / Orexin Receptors / Orexin Receptor Antagonists / Sleep Aids, Pharmaceutical Type of study: Clinical_trials Limits: Animals / Female / Humans / Male Language: En Journal: Sci Rep Year: 2016 Type: Article Affiliation country: United States