Biotransformation of Salpichrolides A, C, and G by Three Filamentous Fungi.
J Nat Prod
; 79(6): 1658-67, 2016 06 24.
Article
in En
| MEDLINE
| ID: mdl-27285201
ABSTRACT
Incubation of salpichrolide A (1) with Rhizomucor miehei produced hydroxylation in rings B and C (C-7 and C-12) and led to C-5-C-6 epoxide opening, while incubation of salpichrolides C (2) and G (3) with R. miehei led to epoxide opening at the C-24-C-25 and C-5-C-6 positions, respectively. Biotransformation of salpichrolide A (1) with Cunninghamella elegans produced stereoselective hydroxylated, oxidized, and reduced derivatives in different positions of the A, B, and C rings and C-5-C-6 epoxide opening. In addition, selective epoxide opening at the C-5-C-6 or C-24-C-25 positions was obtained from the incubation of salpichrolide A (1) with Curvularia lunata.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ergosterol
/
Fungi
Language:
En
Journal:
J Nat Prod
Year:
2016
Type:
Article
Affiliation country:
Argentina