VLA-4 blockade by natalizumab inhibits sickle reticulocyte and leucocyte adhesion during simulated blood flow.

White, Jennell; Krishnamoorthy, Sriram; Gupta, Dipti; Lancelot, Moira; Moore, Nancy; Sarnaik, Sharada; Hobbs, William E; Light, David R; Hines, Patrick

White, Jennell; Krishnamoorthy, Sriram; Gupta, Dipti; Lancelot, Moira; Moore, Nancy; Sarnaik, Sharada; Hobbs, William E; Light, David R; Hines, Patrick.

Affiliation

White J; Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.
Krishnamoorthy S; Biogen, Cambridge, MA, USA.
Gupta D; Biogen, Cambridge, MA, USA.
Lancelot M; Division of Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI, USA.
Moore N; Biogen, Cambridge, MA, USA.
Sarnaik S; Division of Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI, USA.
Hobbs WE; Biogen, Cambridge, MA, USA.
Light DR; Biogen, Cambridge, MA, USA.
Hines P; Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.

Br J Haematol ; 174(6): 970-82, 2016 09.

Article in En | MEDLINE | ID: mdl-27291690

Subject(s)

Anemia, Sickle Cell/blood; Cell Adhesion/drug effects; Integrin alpha4beta1/antagonists & inhibitors; Leukocytes/drug effects; Leukocytes/metabolism; Natalizumab/pharmacology; Reticulocytes/drug effects; Reticulocytes/pathology; Adolescent; Adult; Anemia, Sickle Cell/diagnosis; Anemia, Sickle Cell/drug therapy; Biomarkers; Cell Membrane/metabolism; Child; Child, Preschool; Computer Simulation; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Female; Flow Cytometry; Hemodynamics; Humans; Immunoglobulin G/chemistry; Immunoglobulin G/metabolism; Immunoglobulin G/pharmacology; Infant; Male; Middle Aged; Natalizumab/chemistry; Natalizumab/metabolism; Protein Binding; Protein Multimerization; Reticulocytes/metabolism; Vascular Cell Adhesion Molecule-1/metabolism; Young Adult

Key words

adhesion; microfluidics; natalizumab; sickle cell; very late antigen-4

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reticulocytes / Cell Adhesion / Integrin alpha4beta1 / Natalizumab / Anemia, Sickle Cell / Leukocytes Type of study: Diagnostic_studies / Prognostic_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: En Journal: Br J Haematol Year: 2016 Type: Article Affiliation country: United States

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