Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate.
Antimicrob Agents Chemother
; 60(8): 5085-7, 2016 08.
Article
in En
| MEDLINE
| ID: mdl-27297482
ABSTRACT
The aim of this study was to determine the biopharmaceutical characteristics of oseltamivir carboxylate (OC) after pulmonary delivery. After OC bolus and intratracheal nebulization (NEB) in rats, blood was collected and bronchoalveolar lavages (BALs) were performed. Epithelial lining fluid (ELF) concentrations were estimated from BAL fluid. The area under the curve (AUC) ratio for ELF to plasma was 842 times higher after NEB than after intravenous (i.v.) administration, indicating that OC nebulization offers a biopharmaceutical advantage over i.v. administration.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oseltamivir
/
Anti-Infective Agents
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
2016
Type:
Article
Affiliation country:
Brazil