Your browser doesn't support javascript.
loading
Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate.
Galindo Bedor, Danilo Cesar; Marchand, Sandrine; Lamarche, Isabelle; Laroche, Julian; Pereira de Santana, Davi; Couet, William.
Affiliation
  • Galindo Bedor DC; Inserm U1070, Pôle Biologie Santé, Poitiers, France Núcleo de Desenvolvimento Farmacêutico e Cosmético/Departamento de Ciências Farmacêuticas da Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
  • Marchand S; Inserm U1070, Pôle Biologie Santé, Poitiers, France Université de Poitiers, UFR Médecine-Pharmacie, Poitiers, France CHU Poitiers, Service de Toxicologie-Pharmacocinétique, Poitiers, France sandrine.marchand@univ-poitiers.fr.
  • Lamarche I; Inserm U1070, Pôle Biologie Santé, Poitiers, France Université de Poitiers, UFR Médecine-Pharmacie, Poitiers, France.
  • Laroche J; Inserm U1070, Pôle Biologie Santé, Poitiers, France Université de Poitiers, UFR Médecine-Pharmacie, Poitiers, France.
  • Pereira de Santana D; Núcleo de Desenvolvimento Farmacêutico e Cosmético/Departamento de Ciências Farmacêuticas da Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
  • Couet W; Inserm U1070, Pôle Biologie Santé, Poitiers, France Université de Poitiers, UFR Médecine-Pharmacie, Poitiers, France CHU Poitiers, Service de Toxicologie-Pharmacocinétique, Poitiers, France.
Antimicrob Agents Chemother ; 60(8): 5085-7, 2016 08.
Article in En | MEDLINE | ID: mdl-27297482
ABSTRACT
The aim of this study was to determine the biopharmaceutical characteristics of oseltamivir carboxylate (OC) after pulmonary delivery. After OC bolus and intratracheal nebulization (NEB) in rats, blood was collected and bronchoalveolar lavages (BALs) were performed. Epithelial lining fluid (ELF) concentrations were estimated from BAL fluid. The area under the curve (AUC) ratio for ELF to plasma was 842 times higher after NEB than after intravenous (i.v.) administration, indicating that OC nebulization offers a biopharmaceutical advantage over i.v. administration.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oseltamivir / Anti-Infective Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2016 Type: Article Affiliation country: Brazil
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oseltamivir / Anti-Infective Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2016 Type: Article Affiliation country: Brazil