Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation.

Zou, Siying; Teixeira, Alexandra M; Yin, Mingzhu; Xiang, Yaozu; Xavier-Ferrucio, Juliana; Zhang, Ping-Xia; Hwa, John; Min, Wang; Krause, Diane S

Zou, Siying; Teixeira, Alexandra M; Yin, Mingzhu; Xiang, Yaozu; Xavier-Ferrucio, Juliana; Zhang, Ping-Xia; Hwa, John; Min, Wang; Krause, Diane S.

Affiliation

Krause DS; Diane S. Krause, Yale Stem Cell Center, 10 Amistad Street, Room 214I, New Haven, CT 06509, USA, Tel.: +1 203 785 7089, Fax: +1 203 785 4305, E-mail: diane.krause@yale.edu.

Thromb Haemost ; 116(3): 506-16, 2016 08 30.

Article in En | MEDLINE | ID: mdl-27345948

Subject(s)

Blood Platelets/metabolism; Rho Guanine Nucleotide Exchange Factors/blood; rho GTP-Binding Proteins/blood; rhoA GTP-Binding Protein/blood; Animals; Bleeding Time; Blood Platelets/drug effects; Gene Knockdown Techniques; Humans; Megakaryocytes/cytology; Megakaryocytes/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Myosin Light Chains/blood; Platelet Function Tests; Rho Guanine Nucleotide Exchange Factors/antagonists & inhibitors; Rho Guanine Nucleotide Exchange Factors/deficiency; Rho Guanine Nucleotide Exchange Factors/genetics; Thrombin/metabolism; Thrombin/pharmacology; Thrombopoiesis/genetics; Thrombopoiesis/physiology; Thromboxanes/blood; Thromboxanes/pharmacology; rho GTP-Binding Proteins/agonists; rhoA GTP-Binding Protein/agonists

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Rho GTP-Binding Proteins / RhoA GTP-Binding Protein / Rho Guanine Nucleotide Exchange Factors Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Thromb Haemost Year: 2016 Type: Article

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