Comparison of design strategies for a three-arm clinical trial with time-to-event endpoint: Power, time-to-analysis, and operational aspects.

Asikanius, Elina; Rufibach, Kaspar; Bahlo, Jasmin; Bieska, Gabriele; Burger, Hans Ulrich

Asikanius, Elina; Rufibach, Kaspar; Bahlo, Jasmin; Bieska, Gabriele; Burger, Hans Ulrich.

Affiliation

Asikanius E; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Rufibach K; F. Hoffmann-La Roche Ltd, Basel, Switzerland. kaspar.rufibach@roche.com.
Bahlo J; German CLL Study Group, Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Bieska G; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Burger HU; F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Biom J ; 58(6): 1295-1310, 2016 Nov.

Article in En | MEDLINE | ID: mdl-27346746

Subject(s)

Clinical Trials as Topic/methods; Data Interpretation, Statistical; Research Design/standards; Antibodies, Monoclonal, Humanized/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Chlorambucil/therapeutic use; Clinical Trials as Topic/standards; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Time Factors

Key words

Bonferroni correction; Closed hypothesis test; Familywise error rate; Multiarm clinical trial; Multiplicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Research Design / Clinical Trials as Topic / Data Interpretation, Statistical Type of study: Clinical_trials Limits: Humans Language: En Journal: Biom J Year: 2016 Type: Article Affiliation country: Switzerland

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