Stereo-electro-encephalography-Guided Radiofrequency Thermocoagulation: From In Vitro and In Vivo Data to Technical Guidelines.
World Neurosurg
; 94: 73-79, 2016 Oct.
Article
in En
| MEDLINE
| ID: mdl-27373418
ABSTRACT
BACKGROUND:
Deep brain electrodes have been used for the past 10 years to produce bipolar stereo-electro-encephalography-guided radiofrequency thermocoagulation (SEEG RF-TC). However, this technique is based on empiric knowledge. The aim of this study is 3-fold 1) provide in vivo animal data concerning the effect of bipolar RF-TC on brain and its safety; 2) assess the parameters of this procedure (current delivery and dipole selection) that produce the most efficient lesion; and 3) provide technical guidelines.METHODS:
First we achieved in vivo RF-TC on rabbit brains with several conditions (power delivered and lesioning duration) and analyzed their influence on the lesion produced. Only a difference in terms of volume was found, and type of histologic lesions was similar whatever the settings were. We then performed multiple RF-TC in vitro on egg albumen, first with several parameters of radiofrequency and then with different dipole spatial selections. The end point was the size of the radiofrequency thermolesion produced.RESULTS:
Using unfixed parameters of radiofrequency current delivery and increasing it until the power delivered by the generator collapsed produced significantly larger lesions (P = 0.008) than other conditions. Concerning the dipole selection, the use of contiguous contacts on electrodes led to lesions with a higher volume (P = 7.7 × 10-13) than those produced with noncontiguous ones.CONCLUSION:
Besides the target selection in SEEG RF-TC, which is summarized on the basis of a literature review, we report the optimal parameters Radiofrequency current must be increased until the power delivered collapses, and dipoles should be constituted by contiguous electrode contacts.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Stereotaxic Techniques
/
Catheter Ablation
/
Electrocoagulation
/
Electroencephalography
/
Epilepsy
Type of study:
Guideline
Limits:
Animals
Language:
En
Journal:
World Neurosurg
Journal subject:
NEUROCIRURGIA
Year:
2016
Type:
Article