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Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.
Masini, Tiziana; Birkaya, Barbara; van Dijk, Simon; Mondal, Milon; Hekelaar, Johan; Jäger, Manuel; Terwisscha van Scheltinga, Anke C; Patel, Mulchand S; Hirsch, Anna K H; Moman, Edelmiro.
Affiliation
  • Masini T; a Stratingh Institute for Chemistry, University of Groningen , Groningen , The Netherlands.
  • Birkaya B; b Department of Biochemistry , School of Medicine and Biomedical Sciences, University at Buffalo, the State University of New York , Buffalo , NY , USA.
  • van Dijk S; a Stratingh Institute for Chemistry, University of Groningen , Groningen , The Netherlands.
  • Mondal M; a Stratingh Institute for Chemistry, University of Groningen , Groningen , The Netherlands.
  • Hekelaar J; c Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen , Groningen , The Netherlands.
  • Jäger M; a Stratingh Institute for Chemistry, University of Groningen , Groningen , The Netherlands.
  • Terwisscha van Scheltinga AC; c Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen , Groningen , The Netherlands.
  • Patel MS; b Department of Biochemistry , School of Medicine and Biomedical Sciences, University at Buffalo, the State University of New York , Buffalo , NY , USA.
  • Hirsch AK; a Stratingh Institute for Chemistry, University of Groningen , Groningen , The Netherlands.
  • Moman E; d Molecular Design Group, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin , Ireland , and.
J Enzyme Inhib Med Chem ; 31(sup4): 170-175, 2016.
Article in En | MEDLINE | ID: mdl-27435185
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / Protein Serine-Threonine Kinases / Pyruvic Acid / Protein Kinase Inhibitors / Furans Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: Netherlands
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / Protein Serine-Threonine Kinases / Pyruvic Acid / Protein Kinase Inhibitors / Furans Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: Netherlands