MLH1-deficient Colorectal Carcinoma With Wild-type BRAF and MLH1 Promoter Hypermethylation Harbor KRAS Mutations and Arise From Conventional Adenomas.

Farchoukh, Lama; Kuan, Shih-Fan; Dudley, Beth; Brand, Randall; Nikiforova, Marina; Pai, Reetesh K

Farchoukh, Lama; Kuan, Shih-Fan; Dudley, Beth; Brand, Randall; Nikiforova, Marina; Pai, Reetesh K.

Affiliation

Farchoukh L; *Department of Pathology Department of Internal Medicine, Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA.

Am J Surg Pathol ; 40(10): 1390-9, 2016 10.

Article in En | MEDLINE | ID: mdl-27438990

Subject(s)

Adenocarcinoma/genetics; Adenoma/genetics; Colorectal Neoplasms/genetics; DNA Methylation; MutL Protein Homolog 1/deficiency; Proto-Oncogene Proteins B-raf/genetics; Proto-Oncogene Proteins p21(ras)/genetics; Adenocarcinoma/mortality; Adenocarcinoma/pathology; Adenoma/mortality; Adenoma/pathology; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor/deficiency; Biomarkers, Tumor/genetics; Case-Control Studies; Colorectal Neoplasms/mortality; Colorectal Neoplasms/pathology; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics; Databases, Factual; Female; Follow-Up Studies; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Microsatellite Instability; Middle Aged; MutL Protein Homolog 1/genetics; Mutation; Promoter Regions, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Adenocarcinoma / Adenoma / Proto-Oncogene Proteins p21(ras) / DNA Methylation / Proto-Oncogene Proteins B-raf / MutL Protein Homolog 1 Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Am J Surg Pathol Year: 2016 Type: Article Affiliation country: Panama

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