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Mapping and analyzing the human liver proteome: progress and potential.
Yu, Hongxiu; Wang, Fang; Lin, Ling; Cao, Weiqian; Liu, Yinkun; Qin, Lunxiu; Lu, Haojie; He, Fuchu; Shen, Huali; Yang, Pengyuan.
Affiliation
  • Yu H; a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.
  • Wang F; b Minhang Hospital and Institutes of Biomedical Sciences , Fudan University , Shanghai , China.
  • Lin L; a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.
  • Cao W; a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.
  • Liu Y; a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.
  • Qin L; c China Liver Cancer Institute, Zhongshan Hospital , Fudan University , Shanghai , China.
  • Lu H; c China Liver Cancer Institute, Zhongshan Hospital , Fudan University , Shanghai , China.
  • He F; b Minhang Hospital and Institutes of Biomedical Sciences , Fudan University , Shanghai , China.
  • Shen H; d State Key Laboratory of Proteomics, Beijing Proteome Research Center , Beijing Institute of Radiation Medicine , Beijing , China.
  • Yang P; a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.
Expert Rev Proteomics ; 13(9): 833-43, 2016 09.
Article in En | MEDLINE | ID: mdl-27448621
ABSTRACT

INTRODUCTION:

The liver is an important organ in humans. Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world. Progress in the Human Liver Proteome Project (HLPP) has improved understanding of the liver and the liver cancer proteome. AREAS COVERED Here, we summarize the recent progress in liver proteome modification profiles, proteomic studies in liver cancer, proteomic study in the search for novel liver cancer biomarkers and drug targets, and progress of the Chromosome Centric Human Proteome Project (CHPP) in the past five years in the Institutes of Biomedical Sciences (IBS) of Fudan University. Expert commentary Recent advances and findings discussed here provide great promise of improving the outcome of patients with liver cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Proteome / Liver / Liver Neoplasms Limits: Humans Language: En Journal: Expert Rev Proteomics Journal subject: BIOQUIMICA Year: 2016 Type: Article Affiliation country: China
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Proteome / Liver / Liver Neoplasms Limits: Humans Language: En Journal: Expert Rev Proteomics Journal subject: BIOQUIMICA Year: 2016 Type: Article Affiliation country: China