Somatic mosaicism in B cells of a patient with autosomal dominant hyper IgE syndrome.

Alcántara-Montiel, Julio C; Staines-Boone, Tamara; López-Herrera, Gabriela; Berrón-Ruiz, Laura; Borrego-Montoya, Carlos R; Santos-Argumedo, Leopoldo

Alcántara-Montiel, Julio C; Staines-Boone, Tamara; López-Herrera, Gabriela; Berrón-Ruiz, Laura; Borrego-Montoya, Carlos R; Santos-Argumedo, Leopoldo.

Affiliation

Alcántara-Montiel JC; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico.
Staines-Boone T; FES Zaragoza, National Autonomous University of Mexico, Mexico City.
López-Herrera G; Hospital of High Specialties #25, IMSS, Monterrey, Nuevo Leon, Mexico.
Berrón-Ruiz L; Immunodeficiencies Research Unit, National Institute of Pediatrics, Mexico City.
Borrego-Montoya CR; Immunodeficiencies Research Unit, National Institute of Pediatrics, Mexico City.
Santos-Argumedo L; Hospital of High Specialties #25, IMSS, Monterrey, Nuevo Leon, Mexico.

Eur J Immunol ; 46(10): 2438-2443, 2016 10.

Article in En | MEDLINE | ID: mdl-27488252

Subject(s)

B-Lymphocytes/physiology; Job Syndrome/immunology; Mosaicism; Mutation/genetics; STAT3 Transcription Factor/genetics; Th17 Cells/physiology; Adult; Cells, Cultured; Female; Genetic Counseling; Genotype; Humans; Immunoglobulin E/metabolism; Immunologic Memory; Interleukin-17/metabolism; Job Syndrome/diagnosis; Male; Organ Specificity; Phenotype; Phosphorylation/genetics; STAT3 Transcription Factor/metabolism; Young Adult

Key words

Hyper IgE syndrome; IL-17A; STAT3 phosphorylation; Somatic mosaic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / STAT3 Transcription Factor / Th17 Cells / Job Syndrome / Mosaicism / Mutation Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Eur J Immunol Year: 2016 Type: Article Affiliation country: Mexico

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