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A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.
Kim, Han Sang; Cheon, Jae Hee; Jung, Eun Suk; Park, Joonhee; Aum, Sowon; Park, Soo Jung; Eun, Sungho; Lee, Jinu; Rüther, Ulrich; Yeo, Giles S H; Ma, Marcella; Park, Kyong Soo; Naito, Takeo; Kakuta, Yoichi; Lee, Ji Hyun; Kim, Won Ho; Lee, Min Goo.
Affiliation
  • Kim HS; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.
  • Cheon JH; Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Jung ES; Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
  • Park J; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
  • Aum S; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.
  • Park SJ; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
  • Eun S; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.
  • Lee J; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.
  • Rüther U; Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
  • Yeo GSH; Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.
  • Ma M; College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Inchon, Korea.
  • Park KS; Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, Universitätsstr. 1, Düsseldorf, Germany.
  • Naito T; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Kakuta Y; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
  • Lee JH; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • Kim WH; Division of Gastroenterology, Tohoku University Hospital, Miyagi, Japan.
  • Lee MG; Division of Gastroenterology, Tohoku University Hospital, Miyagi, Japan.
Gut ; 66(11): 1926-1935, 2017 11.
Article in En | MEDLINE | ID: mdl-27558924
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azathioprine / Inflammatory Bowel Diseases / Polymorphism, Single Nucleotide / Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Immunosuppressive Agents / Leukopenia / Mercaptopurine Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Gut Year: 2017 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azathioprine / Inflammatory Bowel Diseases / Polymorphism, Single Nucleotide / Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Immunosuppressive Agents / Leukopenia / Mercaptopurine Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Gut Year: 2017 Type: Article