Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition.

Yao, Weilong; Oh, You-Take; Deng, Jiusheng; Yue, Ping; Deng, Liang; Huang, Henry; Zhou, Wei; Sun, Shi-Yong

Yao, Weilong; Oh, You-Take; Deng, Jiusheng; Yue, Ping; Deng, Liang; Huang, Henry; Zhou, Wei; Sun, Shi-Yong.

Affiliation

Yao W; From the Xiangya School of Medicine, Central South University, Changsha, Hunan, China 410008 and.
Oh YT; the Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322.
Deng J; the Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322.
Yue P; the Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322.
Deng L; the Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322.
Huang H; From the Xiangya School of Medicine, Central South University, Changsha, Hunan, China 410008 and.
Zhou W; the Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322.
Sun SY; the Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322.

J Biol Chem ; 291(41): 21694-21702, 2016 Oct 07.

Article in En | MEDLINE | ID: mdl-27576686

Subject(s)

Gene Expression Regulation, Neoplastic; MAP Kinase Signaling System; Neoplasms/metabolism; Receptors, TNF-Related Apoptosis-Inducing Ligand/biosynthesis; Transcription Factor AP-1/metabolism; Transcriptional Activation; Amino Acid Substitution; Cell Line, Tumor; HEK293 Cells; Humans; Mutation, Missense; Neoplasms/genetics; Neoplasms/pathology; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins B-raf/genetics; Proto-Oncogene Proteins B-raf/metabolism; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics; TNF-Related Apoptosis-Inducing Ligand/genetics; TNF-Related Apoptosis-Inducing Ligand/metabolism; Transcription Factor AP-1/genetics

Key words

AP1 transcription factor (AP-1); DR4; MEK; Trail; apoptosis; cancer biology; gene expression

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Transcriptional Activation / Transcription Factor AP-1 / MAP Kinase Signaling System / Receptors, TNF-Related Apoptosis-Inducing Ligand / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2016 Type: Article

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