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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Tice, Colin M; Noto, Paul B; Fan, Kristi Yi; Zhao, Wei; Lotesta, Stephen D; Dong, Chengguo; Marcus, Andrew P; Zheng, Ya-Jun; Chen, Guozhou; Wu, Zhongren; Van Orden, Rebecca; Zhou, Jing; Bukhtiyarov, Yuri; Zhao, Yi; Lipinski, Kerri; Howard, Lamont; Guo, Joan; Kandpal, Geeta; Meng, Shi; Hardy, Andrew; Krosky, Paula; Gregg, Richard E; Leftheris, Katerina; McKeever, Brian M; Singh, Suresh B; Lala, Deepak; McGeehan, Gerard M; Zhuang, Linghang; Claremon, David A.
Affiliation
  • Tice CM; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Noto PB; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Fan KY; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Zhao W; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Lotesta SD; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Dong C; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Marcus AP; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Zheng YJ; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Chen G; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Wu Z; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Van Orden R; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Zhou J; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Bukhtiyarov Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Zhao Y; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Lipinski K; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Howard L; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Guo J; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Kandpal G; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Meng S; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Hardy A; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Krosky P; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Gregg RE; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Leftheris K; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • McKeever BM; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Singh SB; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Lala D; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • McGeehan GM; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Zhuang L; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
  • Claremon DA; Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, USA.
Bioorg Med Chem Lett ; 26(20): 5044-5050, 2016 10 15.
Article in En | MEDLINE | ID: mdl-27599745
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Liver X Receptors Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Liver X Receptors Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: United States