Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes.

Gorbatenko, Andrej; Olesen, Christina W; Loebl, Nathalie; Sigurdsson, Haraldur H; Bianchi, Carolina; Pedraz-Cuesta, Elena; Christiansen, Jan; Pedersen, Stine Falsig

Gorbatenko, Andrej; Olesen, Christina W; Loebl, Nathalie; Sigurdsson, Haraldur H; Bianchi, Carolina; Pedraz-Cuesta, Elena; Christiansen, Jan; Pedersen, Stine Falsig.

Affiliation

Gorbatenko A; Section for Cell Biology and Physiology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
Olesen CW; Section for Cell Biology and Physiology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
Loebl N; Section for Cell Biology and Physiology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
Sigurdsson HH; Section for Cell Biology and Physiology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
Bianchi C; Section for Cell Biology and Physiology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
Pedraz-Cuesta E; Section for Cell Biology and Physiology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
Christiansen J; Section for Computational and RNA Biology, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Pedersen SF; Section for Cell Biology and Physiology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.

Biochem J ; 473(21): 4027-4044, 2016 11 01.

Article in En | MEDLINE | ID: mdl-27609814

Subject(s)

3' Untranslated Regions/genetics; Breast Neoplasms/metabolism; Receptor, ErbB-2/metabolism; Sodium-Bicarbonate Symporters/metabolism; Blotting, Western; Breast Neoplasms/genetics; Electrophoretic Mobility Shift Assay; Female; Fluorescent Antibody Technique; Humans; MCF-7 Cells; RNA Stability/genetics; RNA Stability/physiology; Real-Time Polymerase Chain Reaction; Receptor, ErbB-2/genetics; Sodium-Bicarbonate Symporters/genetics

Key words

HER2; HuR; microRNA; pH regulation; posttranscriptional regulation; sodium bicarbonate transport

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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Receptor, ErbB-2 / 3' Untranslated Regions / Sodium-Bicarbonate Symporters Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Biochem J Year: 2016 Type: Article Affiliation country: Denmark

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