Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher.

Ginsberg, Henry N; Rader, Daniel J; Raal, Frederick J; Guyton, John R; Baccara-Dinet, Marie T; Lorenzato, Christelle; Pordy, Robert; Stroes, Erik

Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher.

Ginsberg, Henry N; Rader, Daniel J; Raal, Frederick J; Guyton, John R; Baccara-Dinet, Marie T; Lorenzato, Christelle; Pordy, Robert; Stroes, Erik.

Affiliation

Ginsberg HN; Columbia University College of Physicians and Surgeons, Irving Institute for Clinical and Translational Research, Columbia University, 622 West 168th Street, New York, NY, 10032, USA. hng1@cumc.columbia.edu.
Rader DJ; Departments of Medicine and Genetics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.
Raal FJ; Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Guyton JR; Duke University Medical Center, Durham, NC, USA.
Baccara-Dinet MT; Sanofi, Montpellier, France.
Lorenzato C; Sanofi, Paris, France.
Pordy R; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.
Stroes E; Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

Cardiovasc Drugs Ther ; 30(5): 473-483, 2016 Oct.

Article in En | MEDLINE | ID: mdl-27618825

Subject(s)

Antibodies, Monoclonal/therapeutic use; Anticholesteremic Agents/therapeutic use; Cholesterol, LDL/blood; Hyperlipoproteinemia Type II/drug therapy; Adult; Antibodies, Monoclonal, Humanized; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use; Hyperlipoproteinemia Type II/blood; Male; Middle Aged; PCSK9 Inhibitors; Proprotein Convertase 9/immunology; Treatment Outcome

Key words

Alirocumab; Cardiovascular disease prevention; Cholesterol-lowering drugs; Familial hypercholesterolemia; LDL-C; PCSK9

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hyperlipoproteinemia Type II / Cholesterol, LDL / Antibodies, Monoclonal / Anticholesteremic Agents Type of study: Clinical_trials Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Cardiovasc Drugs Ther Journal subject: ANGIOLOGIA / CARDIOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2016 Type: Article Affiliation country: United States

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