A Case of Giant Borderline Phyllodes Tumor of the Breast Associated with Hypoglycemia.
Tokai J Exp Clin Med
; 41(3): 118-22, 2016 Sep 20.
Article
in En
| MEDLINE
| ID: mdl-27628602
ABSTRACT
We report a patient with a giant phyllodes tumor of the right breast associated with a hypoglycemic attack. A 48-year-old woman experienced a loss of consciousness and was transferred via ambulance to our hospital emergency department. Upon arrival, her blood glucose level was 26 mg/dl, and a giant tumor (>20 cm in diameter) with skin ulceration was observed on the right breast. Core needle biopsy led to a histological diagnosis of a phyllodes tumor of the breast. Ultrasonography and computed tomography detected neither distant metastasis nor a pancreatic endocrine tumor. Her preoperative serum insulin-like growth factor (IGF)-II and insulin levels were 1,330 ng/ml (normal range, 519-1067 ng/ml) and <1.0 µU/ml, respectively. Following a simple mastectomy, the 24-h postoperative serum IGF-II and insulin levels were 496 ng/ml and 10.0 µU/ml, respectively. The IGF-II levels detected in the phyllodes tumor and normal breast tissue were 10,600 ng/Wg (wet weight in grams) and 855 ng/Wg. We conclude from these findings that the hypoglycemic attack was related to the elevated IGF-II level in the giant phyllodes tumor of the breast.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Insulin-Like Growth Factor II
/
Phyllodes Tumor
/
Hypoglycemia
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Tokai J Exp Clin Med
Year:
2016
Type:
Article
Affiliation country:
Japan