Metformin Increases E-cadherin in Tumors of Diabetic Patients With Endometrial Cancer and Suppresses Epithelial-Mesenchymal Transition in Endometrial Cancer Cell Lines.

Laskov, Ido; Abou-Nader, Paul; Amin, Oreekha; Philip, Charles-Andre; Beauchamp, Marie-Claude; Yasmeen, Amber; Gotlieb, Walter H

Laskov, Ido; Abou-Nader, Paul; Amin, Oreekha; Philip, Charles-Andre; Beauchamp, Marie-Claude; Yasmeen, Amber; Gotlieb, Walter H.

Affiliation

Laskov I; *Division of Gynecologic Oncology, Jewish General Hospital; Segal Cancer Center, Lady Davis Institute of Medical Research; and Department of Oncology, McGill University, Montreal, Quebec, Canada.

Int J Gynecol Cancer ; 26(7): 1213-21, 2016 09.

Article in En | MEDLINE | ID: mdl-27643646

Subject(s)

Carcinoma/drug therapy; Endometrial Neoplasms/drug therapy; Epithelial-Mesenchymal Transition/drug effects; Hypoglycemic Agents/therapeutic use; Metformin/therapeutic use; Adult; Aged; Aged, 80 and over; Cadherins/metabolism; Carcinoma/complications; Carcinoma/metabolism; Cell Line, Tumor; Cell Movement/drug effects; Diabetes Mellitus, Type 2/drug therapy; Drug Screening Assays, Antitumor; Endometrial Neoplasms/complications; Endometrial Neoplasms/metabolism; Female; Humans; Hypoglycemic Agents/pharmacology; Keratins/metabolism; Metformin/pharmacology; Middle Aged; Pilot Projects; Retrospective Studies

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma / Endometrial Neoplasms / Epithelial-Mesenchymal Transition / Hypoglycemic Agents / Metformin Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Middle aged Language: En Journal: Int J Gynecol Cancer Journal subject: GINECOLOGIA / NEOPLASIAS Year: 2016 Type: Article Affiliation country: Canada

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