Cancer and treatment-related symptoms are associated with mobility disability in women with ovarian cancer: A cross-sectional study.
Gynecol Oncol
; 143(3): 578-583, 2016 Dec.
Article
in En
| MEDLINE
| ID: mdl-27653982
ABSTRACT
OBJECTIVE:
To examine the prevalence of symptom-related mobility disability and identify specific symptoms and other factors associated with mobility disability among a national sample of ovarian cancer (OC) survivors.METHODS:
Descriptive, correlational secondary analysis of a National Ovarian Cancer Coalition mailed survey of women with a history of OC (n=713). We used the Symptom Representation Questionnaire (SRQ), the MD Anderson Symptom Inventory (MDASI) Interference Scale, and medical and demographic information to determine prevalence of symptom-related mobility disability. We constructed a multiple linear regression model to determine the relative contributions of specific symptoms and other factors to mobility disability.RESULTS:
A majority of the sample (60.0%) reported symptom-related mobility disability. Independent predictors included > one comorbidity (ß=0.112, p=0.001), active OC (ß=0.111, p=0.037), abdominal bloating (ß=0.097, p=0.006), fatigue (ß=0.314, p<0.001), lack of appetite (ß=0.072, p=0.045), numbness/tingling (ß=0.134, p<0.001), and pain (ß=0.194, p<0.001). The model explained 41.5% of the variance in symptom-related mobility disability (R2=0.415). Unexpectedly, age (ß=-0.028, p=0.412) and current chemotherapy (ß=0.107, p=0.118) were not significant predictors.CONCLUSIONS:
Symptom-related mobility disability is common among women with OC and is associated with medical comorbidities, abdominal bloating, fatigue, lack of appetite, numbness/tingling, and pain. Longitudinal research should clarify the relationship of these symptoms to mobility disability and determine whether effective symptom management minimizes disability.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Anorexia
/
Peripheral Nervous System Diseases
/
Mobility Limitation
/
Fatigue
/
Cancer Pain
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Gynecol Oncol
Year:
2016
Type:
Article