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Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.
Wang, Rongsheng E; Wang, Ying; Zhang, Yuhan; Gabrelow, Chase; Zhang, Yong; Chi, Victor; Fu, Qiangwei; Luo, Xiaozhou; Wang, Danling; Joseph, Sean; Johnson, Kristen; Chatterjee, Arnab K; Wright, Timothy M; Nguyen-Tran, Vân T B; Teijaro, John; Theofilopoulos, Argyrios N; Schultz, Peter G; Wang, Feng.
Affiliation
  • Wang RE; Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Wang Y; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Zhang Y; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Gabrelow C; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Zhang Y; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Chi V; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Fu Q; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Luo X; Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Wang D; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Joseph S; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Johnson K; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Chatterjee AK; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Wright TM; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Nguyen-Tran VT; California Institute for Biomedical Research, La Jolla, CA 92037.
  • Teijaro J; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037.
  • Theofilopoulos AN; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037.
  • Schultz PG; Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037; California Institute for Biomedical Research, La Jolla, CA 92037; schultz@scripps.edu fwang@calibr.org.
  • Wang F; California Institute for Biomedical Research, La Jolla, CA 92037; schultz@scripps.edu fwang@calibr.org.
Proc Natl Acad Sci U S A ; 113(41): 11501-11506, 2016 10 11.
Article in En | MEDLINE | ID: mdl-27663736
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Antibodies, Blocking / Kv1.3 Potassium Channel / Immunosuppressive Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Antibodies, Blocking / Kv1.3 Potassium Channel / Immunosuppressive Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Type: Article