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Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone.
Ramirez-Carrozzi, Vladimir; Sambandam, Arivazhagan; Zhou, Meijuan; Yan, Donghong; Kang, Jing; Wu, Xiumin; Suto, Eric; Baca, Miriam; Austin, Cary; Xu, Min; Lee, Wyne; Pappu, Rajita.
Affiliation
  • Ramirez-Carrozzi V; Department of Immunology Discovery, Genentech, South San Francisco, Calif.
  • Sambandam A; Department of Immunology Discovery, Genentech, South San Francisco, Calif.
  • Zhou M; Department of Translational Immunology, Genentech, South San Francisco, Calif.
  • Yan D; Department of Translational Immunology, Genentech, South San Francisco, Calif.
  • Kang J; Department of Translational Immunology, Genentech, South San Francisco, Calif.
  • Wu X; Department of Translational Immunology, Genentech, South San Francisco, Calif.
  • Suto E; Department of Translational Immunology, Genentech, South San Francisco, Calif.
  • Baca M; Department of Pathology, Genentech, South San Francisco, Calif.
  • Austin C; Department of Pathology, Genentech, South San Francisco, Calif.
  • Xu M; Department of Translational Immunology, Genentech, South San Francisco, Calif.
  • Lee W; Department of Translational Immunology, Genentech, South San Francisco, Calif.
  • Pappu R; Department of Immunology Discovery, Genentech, South San Francisco, Calif. Electronic address: rajitap@gene.com.
J Allergy Clin Immunol ; 139(2): 705-708.e6, 2017 02.
Article in En | MEDLINE | ID: mdl-27697499
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Signal Transduction / Strongylida Infections / Interleukin-13 / Antibodies, Blocking / Interleukin-33 / Nippostrongylus Limits: Animals Language: En Journal: J Allergy Clin Immunol Year: 2017 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Signal Transduction / Strongylida Infections / Interleukin-13 / Antibodies, Blocking / Interleukin-33 / Nippostrongylus Limits: Animals Language: En Journal: J Allergy Clin Immunol Year: 2017 Type: Article