Empowering Older Antibiotics.
Cell
; 167(2): 301, 2016 Oct 06.
Article
in En
| MEDLINE
| ID: mdl-27716499
ABSTRACT
Avycaz combines an older cephalosporin antibiotic, ceftazidime, and the ß-lactamase inhibitor avibactam. Ceftazidime targets penicillin-binding proteins (PBPs) in the bacterial periplasm that are required for cell wall synthesis. Avibactam blocks ß-lactamases (ß-L) in the periplasm, which would otherwise inactivate the antibiotics resulting in drug resistance.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacteria
/
Ceftazidime
/
Penicillin-Binding Proteins
/
Azabicyclo Compounds
/
Beta-Lactamase Inhibitors
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Cell
Year:
2016
Type:
Article