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Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.
Marcotte, Douglas; Rushe, Mia; M Arduini, Robert; Lukacs, Christine; Atkins, Kateri; Sun, Xin; Little, Kevin; Cullivan, Michael; Paramasivam, Murugan; Patterson, Thomas A; Hesson, Thomas; D McKee, Timothy; May-Dracka, Tricia L; Xin, Zhili; Bertolotti-Ciarlet, Andrea; Bhisetti, Govinda R; Lyssikatos, Joseph P; Silvian, Laura F.
Affiliation
  • Marcotte D; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Rushe M; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • M Arduini R; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Lukacs C; Beryllium Discovery Corp., 3 Preston Court, Bedford, MA, 01730.
  • Atkins K; Beryllium Discovery Corp., 3 Preston Court, Bedford, MA, 01730.
  • Sun X; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Little K; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Cullivan M; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Paramasivam M; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Patterson TA; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Hesson T; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • D McKee T; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • May-Dracka TL; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Xin Z; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Bertolotti-Ciarlet A; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Bhisetti GR; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Lyssikatos JP; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
  • Silvian LF; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.
Protein Sci ; 26(2): 152-162, 2017 02.
Article in En | MEDLINE | ID: mdl-27727493
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Mutation, Missense / Protein Kinase Inhibitors Limits: Humans Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 2017 Type: Article
Fulltext
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XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Mutation, Missense / Protein Kinase Inhibitors Limits: Humans Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 2017 Type: Article