Lung transplantation for high-risk patients with idiopathic pulmonary fibrosis.
Sarcoidosis Vasc Diffuse Lung Dis
; 33(3): 235-241, 2016 Oct 07.
Article
in En
| MEDLINE
| ID: mdl-27758988
ABSTRACT
BACKGROUND:
Survival for patients with idiopathic pulmonary fibrosis (IPF) and high lung allocation score (LAS) values may be significantly reduced in comparison to those with lower LAS values.OBJECTIVES:
To evaluate outcomes for high-risk IPF patients as defined by LAS values ≥46 (N=42) versus recipients with LAS values <46 (N=89).METHODS:
We retrospectively reviewed records of 131 consecutive patients with IPF who received lung transplants at our institution between 1999 and 2013.RESULTS:
The mean LAS was significantly higher (59.5, interquartile range 43.9-75.9 vs. 39.3, interquartile range 37.7-44.3; p<0.01) for the high-risk cohort. The higher LAS cohort had significantly lower percent predicted forced vital capacity (FVC) versus recipients with LAS <46 (41.3±14.1% vs. 53.2±16.2%; p<0.01) and required more supplemental oxygen (7±5 vs. 4±2 L/min, p<0.01) prior to transplant versus recipients with LAS <46. Although the incidence of early post-LTX pulmonary complications was increased for the higher LAS group versus recipients with LAS <46, 30-day mortality and actuarial survival did not differ between the two cohorts.CONCLUSIONS:
Although lung transplantation in patients with IPF and high LAS values is associated with increased risk of early post-transplant complications, long-term post-transplant survival for our high-LAS cohort was equivalent to that for the lower LAS recipients.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lung Transplantation
/
Idiopathic Pulmonary Fibrosis
/
Lung
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
Sarcoidosis Vasc Diffuse Lung Dis
Journal subject:
ALERGIA E IMUNOLOGIA
/
ANGIOLOGIA
Year:
2016
Type:
Article