Cabozantinib Is Active against Human Gastrointestinal Stromal Tumor Xenografts Carrying Different KIT Mutations.

Gebreyohannes, Yemarshet K; Schöffski, Patrick; Van Looy, Thomas; Wellens, Jasmien; Vreys, Lise; Cornillie, Jasmien; Vanleeuw, Ulla; Aftab, Dana T; Debiec-Rychter, Maria; Sciot, Raf; Wozniak, Agnieszka

Gebreyohannes, Yemarshet K; Schöffski, Patrick; Van Looy, Thomas; Wellens, Jasmien; Vreys, Lise; Cornillie, Jasmien; Vanleeuw, Ulla; Aftab, Dana T; Debiec-Rychter, Maria; Sciot, Raf; Wozniak, Agnieszka.

Affiliation

Gebreyohannes YK; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.
Schöffski P; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.
Van Looy T; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.
Wellens J; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.
Vreys L; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.
Cornillie J; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.
Vanleeuw U; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.
Aftab DT; Exelixis Inc., South San Francisco, California.
Debiec-Rychter M; Department of Human Genetics, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
Sciot R; Department of Pathology, KU Leuven and University Hospitals Leuven, Leuven, Belgium.
Wozniak A; Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium. agnieszka.wozniak@med.kuleuven.be.

Mol Cancer Ther ; 15(12): 2845-2852, 2016 12.

Article in En | MEDLINE | ID: mdl-27777285

Subject(s)

Anilides/pharmacology; Antineoplastic Agents/pharmacology; Gastrointestinal Stromal Tumors/genetics; Mutation; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-kit/genetics; Pyridines/pharmacology; Anilides/chemistry; Animals; Antineoplastic Agents/chemistry; Apoptosis/drug effects; Biopsy; Cell Line, Tumor; Disease Models, Animal; Female; Gastrointestinal Stromal Tumors/drug therapy; Gastrointestinal Stromal Tumors/pathology; Humans; Imatinib Mesylate/pharmacology; Mice; Necrosis; Neoplasm Grading; Neovascularization, Pathologic/drug therapy; Neovascularization, Pathologic/metabolism; Neovascularization, Pathologic/pathology; Protein Kinase Inhibitors/chemistry; Proto-Oncogene Proteins c-kit/metabolism; Pyridines/chemistry; Signal Transduction/drug effects; Tumor Burden/drug effects; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Proto-Oncogene Proteins c-kit / Gastrointestinal Stromal Tumors / Protein Kinase Inhibitors / Anilides / Mutation / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2016 Type: Article Affiliation country: Belgium

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