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Discovery of Chromane Containing Hepatitis C Virus (HCV) NS5A Inhibitors with Improved Potency against Resistance-Associated Variants.
Yu, Wensheng; Tong, Ling; Hu, Bin; Zhong, Bin; Hao, Jinglai; Ji, Tao; Zan, Shuai; Coburn, Craig A; Selyutin, Oleg; Chen, Lei; Rokosz, Laura; Agrawal, Sony; Liu, Rong; Curry, Stephanie; McMonagle, Patricia; Ingravallo, Paul; Asante-Appiah, Ernest; Chen, Shiying; Kozlowski, Joseph A.
Affiliation
  • Yu W; Department of Medicinal Chemistry, Merck Research Laboratories , 126 East Lincoln Avenue, Rahway New Jersey 07065, United States.
  • Tong L; Department of Medicinal Chemistry, Merck Research Laboratories , 126 East Lincoln Avenue, Rahway New Jersey 07065, United States.
  • Hu B; WuXi AppTec , 288 Fute Zhong Road, Shanghai, 200131, China.
  • Zhong B; WuXi AppTec , 288 Fute Zhong Road, Shanghai, 200131, China.
  • Hao J; WuXi AppTec , 288 Fute Zhong Road, Shanghai, 200131, China.
  • Ji T; WuXi AppTec , 288 Fute Zhong Road, Shanghai, 200131, China.
  • Zan S; WuXi AppTec , 288 Fute Zhong Road, Shanghai, 200131, China.
  • Coburn CA; Department of Medicinal Chemistry, Merck Research Laboratories , 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States.
  • Selyutin O; Department of Medicinal Chemistry, Merck Research Laboratories , 126 East Lincoln Avenue, Rahway New Jersey 07065, United States.
  • Chen L; Department of Medicinal Chemistry, Merck Research Laboratories , 126 East Lincoln Avenue, Rahway New Jersey 07065, United States.
  • Rokosz L; Department of in Vitro Pharmacology, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Agrawal S; Department of in Vitro Pharmacology, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Liu R; Department of Infectious Diseases, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Curry S; Department of Infectious Diseases, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • McMonagle P; Department of Infectious Diseases, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Ingravallo P; Department of Infectious Diseases, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Asante-Appiah E; Department of Infectious Diseases, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Chen S; Department of PPDM, Merck Research Laboratories , 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.
  • Kozlowski JA; Department of Medicinal Chemistry, Merck Research Laboratories , 126 East Lincoln Avenue, Rahway New Jersey 07065, United States.
J Med Chem ; 59(22): 10228-10243, 2016 11 23.
Article in En | MEDLINE | ID: mdl-27792320
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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Chromans / Viral Nonstructural Proteins / Hepacivirus / Drug Resistance, Viral / Drug Discovery Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Type: Article Affiliation country: United States
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Chromans / Viral Nonstructural Proteins / Hepacivirus / Drug Resistance, Viral / Drug Discovery Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Type: Article Affiliation country: United States