Exploring Human Diseases and Biological Mechanisms by Protein Structure Prediction and Modeling.

Wang, Juexin; Luttrell, Joseph; Zhang, Ning; Khan, Saad; Shi, NianQing; Wang, Michael X; Kang, Jing-Qiong; Wang, Zheng; Xu, Dong

Wang, Juexin; Luttrell, Joseph; Zhang, Ning; Khan, Saad; Shi, NianQing; Wang, Michael X; Kang, Jing-Qiong; Wang, Zheng; Xu, Dong.

Affiliation

Wang J; Department of Computer Science, University of Missouri, Columbia, MO, 65211, USA.
Luttrell J; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.
Zhang N; School of Computing, University of Southern Mississippi, 118 College Drive, Hattiesburg, MS, 39406, USA.
Khan S; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.
Shi N; Informatics Institute, University of Missouri, Columbia, MO, 65211, USA.
Wang MX; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA.
Kang JQ; Informatics Institute, University of Missouri, Columbia, MO, 65211, USA.
Wang Z; Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin, Room 8418, 1111 Highland Ave, Madison, WI, 53706, USA.
Xu D; Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, MO, 65211, USA.

Adv Exp Med Biol ; 939: 39-61, 2016.

Article in En | MEDLINE | ID: mdl-27807743

Subject(s)

Brain/metabolism; Computational Biology/methods; Epilepsy/metabolism; Molecular Docking Simulation; Molecular Dynamics Simulation; Precision Medicine/methods; Amino Acid Sequence; Brain/pathology; Caspase 9/chemistry; Caspase 9/genetics; Caspase 9/metabolism; Caveolin 3/chemistry; Caveolin 3/genetics; Caveolin 3/metabolism; Epilepsy/genetics; Epilepsy/pathology; Genome-Wide Association Study; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/chemistry; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism; Ligands; Oryza/genetics; Plant Breeding; Potassium Channels/chemistry; Potassium Channels/genetics; Potassium Channels/metabolism; Protein Binding; Protein Conformation; Receptors, GABA-A/chemistry; Receptors, GABA-A/genetics; Receptors, GABA-A/metabolism; Sequence Alignment; Software

Key words

Biological mechanism; GWAS; Human disease; Plant breeding; Protein misfolding; Protein structure modeling; Protein structure prediction; Sequence mutation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Computational Biology / Epilepsy / Precision Medicine / Molecular Dynamics Simulation / Molecular Docking Simulation Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Adv Exp Med Biol Year: 2016 Type: Article Affiliation country: United States

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