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PEG Grafted-Nanodiamonds for the Delivery of Gemcitabine.
Lu, Mingxia; Wang, Yu-Kai; Zhao, Jiacheng; Lu, Hongxu; Stenzel, Martina H; Xiao, Pu.
Affiliation
  • Lu M; Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Wang YK; Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Zhao J; Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Lu H; Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Stenzel MH; Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Xiao P; Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
Macromol Rapid Commun ; 37(24): 2023-2029, 2016 Dec.
Article in En | MEDLINE | ID: mdl-27813236
ABSTRACT
Carboxyl end-functionalized poly[poly(ethylene glycol) methyl ether methacrylate] [P(PEGMEMA)] and its block copolymer with gemcitabine substituted poly(N-hydroxysuccinimide methacrylate) [PGem-block-P(PEGMEMA)] are synthesized via reversible addition-fragmentation transfer (RAFT) polymerization. Then, two polymers are grafted onto the surface of amine-functionalized nanodiamonds to obtain [P(PEGMEMA)]-grafted nanodiamonds (ND-PEG) and [PGem-block-P(PEGMEMA)]-grafted nanodiamonds (ND-PF). Gemcitabine is physically absorbed to ND-PEG to produce ND-PEG (Gem). Two polymer-grafted nanodiamonds (i.e., with physically absorbed gemcitabine ND-PEG (Gem) and with chemically conjugated gemcitabine ND-PF) are characterized using attenuated total reflectance infrared spectroscopy, dynamic light scattering, and thermogravimetric analysis. The drug release, cytotoxicity (to seed human pancreatic carcinoma AsPC-1 cells), and cellular uptake of ND-PEG (Gem) and ND-PF are also investigated.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Polyethylene Glycols / Drug Delivery Systems / Deoxycytidine / Nanodiamonds Limits: Humans Language: En Journal: Macromol Rapid Commun Year: 2016 Type: Article Affiliation country: Australia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Polyethylene Glycols / Drug Delivery Systems / Deoxycytidine / Nanodiamonds Limits: Humans Language: En Journal: Macromol Rapid Commun Year: 2016 Type: Article Affiliation country: Australia