Efficient synthesis of [<sup>18</sup> F]FPyME: A new approach for the preparation of maleimide-containing prosthetic groups for the conjugation with thiols.

Cavani, Melanie; Bier, Dirk; Holschbach, Marcus; Coenen, Heinz H

Efficient synthesis of [¹⁸ F]FPyME: A new approach for the preparation of maleimide-containing prosthetic groups for the conjugation with thiols.

Cavani, Melanie; Bier, Dirk; Holschbach, Marcus; Coenen, Heinz H.

Affiliation

Cavani M; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry Forschungszentrum Jülich, Jülich, Germany.
Bier D; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry Forschungszentrum Jülich, Jülich, Germany.
Holschbach M; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry Forschungszentrum Jülich, Jülich, Germany.
Coenen HH; Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry Forschungszentrum Jülich, Jülich, Germany.

J Labelled Comp Radiopharm ; 60(1): 87-92, 2017 01.

Article in En | MEDLINE | ID: mdl-27862235

Subject(s)

Pyridines/chemical synthesis; Radiopharmaceuticals/chemical synthesis; Succinimides/chemical synthesis; Maleimides/chemistry; Sulfhydryl Compounds/chemistry

Key words

PET chemistry; [18F]FPyME; fluorine-18; maleimide prosthetic group; protein labelling; thiol reactive reagent

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Succinimides / Radiopharmaceuticals Language: En Journal: J Labelled Comp Radiopharm Year: 2017 Type: Article Affiliation country: Germany

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