Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes.

Endorf, Elizabeth B; Qing, Hua; Aono, Jun; Terami, Naoto; Doyon, Geneviève; Hyzny, Eric; Jones, Karrie L; Findeisen, Hannes M; Bruemmer, Dennis

Endorf, Elizabeth B; Qing, Hua; Aono, Jun; Terami, Naoto; Doyon, Geneviève; Hyzny, Eric; Jones, Karrie L; Findeisen, Hannes M; Bruemmer, Dennis.

Affiliation

Endorf EB; From the Saha Cardiovascular Research Center, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (E.B.E., H.Q., J.A., K.L.J., H.M.F.); and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, UPMC and University
Qing H; From the Saha Cardiovascular Research Center, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (E.B.E., H.Q., J.A., K.L.J., H.M.F.); and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, UPMC and University
Aono J; From the Saha Cardiovascular Research Center, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (E.B.E., H.Q., J.A., K.L.J., H.M.F.); and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, UPMC and University
Terami N; From the Saha Cardiovascular Research Center, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (E.B.E., H.Q., J.A., K.L.J., H.M.F.); and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, UPMC and University
Doyon G; From the Saha Cardiovascular Research Center, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (E.B.E., H.Q., J.A., K.L.J., H.M.F.); and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, UPMC and University
Hyzny E; From the Saha Cardiovascular Research Center, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (E.B.E., H.Q., J.A., K.L.J., H.M.F.); and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, UPMC and University
Jones KL; From the Saha Cardiovascular Research Center, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (E.B.E., H.Q., J.A., K.L.J., H.M.F.); and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, UPMC and University
Findeisen HM; From the Saha Cardiovascular Research Center, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (E.B.E., H.Q., J.A., K.L.J., H.M.F.); and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, UPMC and University
Bruemmer D; From the Saha Cardiovascular Research Center, and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington (E.B.E., H.Q., J.A., K.L.J., H.M.F.); and Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, UPMC and University

Arterioscler Thromb Vasc Biol ; 37(2): 301-311, 2017 Feb.

Article in En | MEDLINE | ID: mdl-27932351

Subject(s)

Atherosclerosis/enzymology; Chromatin Assembly and Disassembly; E2F1 Transcription Factor/metabolism; Gene Silencing; Muscle, Smooth, Vascular/enzymology; Neointima; Telomerase/deficiency; Telomerase/metabolism; Vascular System Injuries/enzymology; Acetylation; Animals; Atherosclerosis/genetics; Atherosclerosis/pathology; Binding Sites; Cell Proliferation; Cells, Cultured; Disease Models, Animal; E2F1 Transcription Factor/genetics; Femoral Artery/enzymology; Femoral Artery/injuries; Femoral Artery/pathology; G1 Phase Cell Cycle Checkpoints; Genetic Predisposition to Disease; Histones/metabolism; Humans; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Smooth, Vascular/injuries; Muscle, Smooth, Vascular/pathology; Phenotype; Phosphorylation; Protein Binding; RNA Interference; Retinoblastoma Protein/metabolism; Signal Transduction; Telomerase/genetics; Time Factors; Transfection; Vascular Remodeling; Vascular System Injuries/genetics; Vascular System Injuries/pathology

Key words

cell proliferation; epigenesist; myocytes; neointima; smooth muscle; telomerase; vascular remodeling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomerase / Gene Silencing / Chromatin Assembly and Disassembly / Atherosclerosis / E2F1 Transcription Factor / Vascular System Injuries / Neointima / Muscle, Smooth, Vascular Type of study: Prognostic_studies Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2017 Type: Article

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