Longitudinal study of cardiometabolic risk from early adolescence to early adulthood in an ethnically diverse cohort.
BMJ Open
; 6(12): e013221, 2016 12 14.
Article
in En
| MEDLINE
| ID: mdl-27979836
ABSTRACT
OBJECTIVE:
To examine influences of adiposity from early adolescence to early 20s on cardiovascular disease (CVD) risk in the multiethnic Determinants of young Adult Social well-being and Health (DASH) longitudinal study.METHODS:
In 2002-2003, 6643 11-13-year-olds from 51 London schools participated at baseline, and 4785 were seen again at 14-16â years. Recently, 665 (97% of invited) participated in pilot follow-up at 21-23â years, with biological and psychosocial measures and blood biomarkers (only at 21-23â years). Regression models examined interplay between ethnicity, adiposity and CVD.RESULTS:
At 21-23â years, â¼30-40% were overweight. About half of the sample had completed a degree with little ethnic variation despite more socioeconomic disadvantage in adolescence among ethnic minorities. Regardless of ethnicity, overweight increased more steeply between 14-16â years and 21-23â years than between 11-13â years and 14-16â years. More overweight among Black Caribbean and Black African females, lower systolic blood pressure (sBP) among Indian females and Pakistani/Bangladeshi males compared with White UK peers, persisted from 11-13â years. At 21-23â years, glycated haemoglobin (HbA1c) was higher among Black Caribbean females, total cholesterol higher and high-density lipoprotein (HDL) cholesterol lower among Pakistani/Bangladeshis. Overweight was associated with a â¼+2â mmâ Hg rise in sBP between 11-13â years and 21-23â years. Adiposity measures at 11-13â years were related to allostatic load (a cluster of several risk markers), HbA1c and HDL cholesterol at 21-23â years. Ethnic patterns in CVD biomarkers remained after adjustments.CONCLUSIONS:
Adolescent adiposity posed significant risks at 21-23â years, a period in the lifespan generally ignored in cardiovascular studies, when ethnic/gender variations in CVD are already apparent.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Ethnicity
/
Black People
/
Asian People
/
White People
/
Adiposity
/
Obesity
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Africa
/
Asia
/
Europa
Language:
En
Journal:
BMJ Open
Year:
2016
Type:
Article
Affiliation country:
United kingdom