Annexin-directed ß-glucuronidase for the targeted treatment of solid tumors.

Guillen, Katrin P; Ruben, Eliza A; Virani, Needa; Harrison, Roger G

Guillen, Katrin P; Ruben, Eliza A; Virani, Needa; Harrison, Roger G.

Affiliation

Guillen KP; Biomedical Engineering Program and School of Chemical, Biological and Materials Engineering, University of Oklahoma, 100 E. Boyd St., Norman, OK 73019, USA.
Ruben EA; Protein Production Core, Department of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, OK 73019, USA.
Virani N; Biomedical Engineering Program and School of Chemical, Biological and Materials Engineering, University of Oklahoma, 100 E. Boyd St., Norman, OK 73019, USA.
Harrison RG; Biomedical Engineering Program and School of Chemical, Biological and Materials Engineering, University of Oklahoma, 100 E. Boyd St., Norman, OK 73019, USA rharrison@ou.edu.

Protein Eng Des Sel ; 30(2): 85-94, 2017 Feb.

Article in En | MEDLINE | ID: mdl-27986920

Subject(s)

Annexin A1/genetics; Annexin A5/genetics; Glucuronidase/metabolism; Recombinant Fusion Proteins/metabolism; Cell Line, Tumor; Glucuronidase/chemistry; Glucuronidase/genetics; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Targeted Therapy; Mutation; Prodrugs/metabolism; Protein Conformation; Protein Stability; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/genetics

Key words

SN-38 glucuronide; enzyme prodrug therapy; phosphatidylserine; vascular targeted; ß-glucuronidase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Annexin A5 / Annexin A1 / Glucuronidase Limits: Humans Language: En Journal: Protein Eng Des Sel Journal subject: BIOQUIMICA / BIOTECNOLOGIA Year: 2017 Type: Article Affiliation country: United States

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