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Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199).
Patel, V M; Balakrishnan, K; Douglas, M; Tibbitts, T; Xu, E Y; Kutok, J L; Ayers, M; Sarkar, A; Guerrieri, R; Wierda, W G; O'Brien, S; Jain, N; Stern, H M; Gandhi, V.
Affiliation
  • Patel VM; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Balakrishnan K; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Douglas M; Infinity Pharmaceuticals Inc., Cambridge, MA, USA.
  • Tibbitts T; Infinity Pharmaceuticals Inc., Cambridge, MA, USA.
  • Xu EY; Infinity Pharmaceuticals Inc., Cambridge, MA, USA.
  • Kutok JL; Infinity Pharmaceuticals Inc., Cambridge, MA, USA.
  • Ayers M; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Sarkar A; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Guerrieri R; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Wierda WG; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • O'Brien S; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Jain N; Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Stern HM; Infinity Pharmaceuticals Inc., Cambridge, MA, USA.
  • Gandhi V; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Leukemia ; 31(9): 1872-1881, 2017 09.
Article in En | MEDLINE | ID: mdl-28017967
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purines / Sulfonamides / Leukemia, Lymphocytic, Chronic, B-Cell / Bridged Bicyclo Compounds, Heterocyclic / Apoptosis Regulatory Proteins / Isoquinolines Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2017 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purines / Sulfonamides / Leukemia, Lymphocytic, Chronic, B-Cell / Bridged Bicyclo Compounds, Heterocyclic / Apoptosis Regulatory Proteins / Isoquinolines Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2017 Type: Article Affiliation country: United States