Creatine Enhances Mitochondrial-Mediated Oligodendrocyte Survival After Demyelinating Injury.

Chamberlain, Kelly A; Chapey, Kristen S; Nanescu, Sonia E; Huang, Jeffrey K

Chamberlain, Kelly A; Chapey, Kristen S; Nanescu, Sonia E; Huang, Jeffrey K.

Affiliation

Chamberlain KA; Department of Biology and.
Chapey KS; Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia 20057.
Nanescu SE; Department of Biology and.
Huang JK; Department of Biology and.

J Neurosci ; 37(6): 1479-1492, 2017 02 08.

Article in En | MEDLINE | ID: mdl-28069926

Subject(s)

Creatine/biosynthesis; Demyelinating Diseases/metabolism; Mitochondria/physiology; Oligodendroglia/physiology; Animals; Cell Lineage/drug effects; Cell Lineage/physiology; Cell Survival/drug effects; Cell Survival/physiology; Cells, Cultured; Creatine/pharmacology; Demyelinating Diseases/pathology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria/drug effects; Oligodendroglia/drug effects

Key words

apoptosis; creatine; demyelination; guanidinoacetate-methyltransferase; oligodendrocyte; regeneration

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligodendroglia / Demyelinating Diseases / Creatine / Mitochondria Limits: Animals Language: En Journal: J Neurosci Year: 2017 Type: Article

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