Dynamic change in the NS3 protease domain in HIV/HCV-coinfected patients naïve to anti-HCV protease inhibitors.
New Microbiol
; 40(1): 53-55, 2017 Jan.
Article
in En
| MEDLINE
| ID: mdl-28072886
ABSTRACT
The genetic analysis of THE natural protease inhibitors (PI) resistance of HCV genotype (GT)1 involves subtypes 1a and 1b. NS3 protease domain was sequentially analysed in 10 HIV/HCV GT1-coinfected individuals naïve to HCV treatment. Analysis at different time points showed that 2/3 GT1b patients were infected by a GT1a clade1 during follow-up. In one patient a switch from clade1 to clade2 and in one other patient a switch from clade2 to clade1 was revealed. Four out of ten patients had resistance-associated substitutions (RASs) at baseline. The dynamics of the dominant infecting subtype suggests the presence of mixed infection in some patients.
Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protease Inhibitors
/
HIV Infections
/
Hepatitis C
/
Viral Nonstructural Proteins
/
Hepacivirus
Limits:
Humans
Language:
En
Journal:
New Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2017
Type:
Article
Affiliation country:
Italy