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Telomerase-specific oncolytic adenovirus expressing TRAIL suppresses peritoneal dissemination of gastric cancer.
Zhou, W; Dai, S; Zhu, H; Song, Z; Cai, Y; Lee, J B; Li, Z; Hu, X; Fang, B; He, C; Huang, X.
Affiliation
  • Zhou W; Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Dai S; Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China.
  • Zhu H; Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Song Z; Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China.
  • Cai Y; Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Lee JB; Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China.
  • Li Z; Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Hu X; Key Laboratory of Biotherapy of Zhejiang province, Hangzhou, China.
  • Fang B; Department of Biochemistry and Molecular Medicine, The George Washington University Medical School, Washington, DC, USA.
  • He C; Department of Biochemistry and Molecular Medicine, The George Washington University Medical School, Washington, DC, USA.
  • Huang X; Department of Biochemistry and Molecular Medicine, The George Washington University Medical School, Washington, DC, USA.
Gene Ther ; 24(4): 199-207, 2017 04.
Article in En | MEDLINE | ID: mdl-28075429
ABSTRACT
Peritoneal dissemination is the most common condition of metastasis in gastric cancer. The survival duration of a patient with advanced stage gastric cancer, may be improved by gene therapy. In this study, we used an oncolytic adenovirus vector (Ad/TRAIL-E1) that expresses both the TRAIL and E1A genes under the control of a tumor-specific promoter. We evaluated the anti-tumor effect of Ad/TRAIL-E1 on gastric cancer cells in vitro, as well as in vivo in a xenograft peritoneal carcinomatosis mouse model. Our data showed that Ad/TRAIL-E1 induced TRAIL-mediated apoptosis in gastric cancer cell lines, but not in the normal cell lines. In addition, Ad/TRAIL-E1 significantly inhibited peritoneal metastasis and prolonged the survival of mice without treatment-related toxicity. Therefore, tumor-specific TRAIL expression from an oncolytic adenovirus vector may provide a novel therapeutic approach for the treatment of advance stage gastric cancer with peritoneal dissemination.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peritoneal Neoplasms / Stomach Neoplasms / Adenovirus E1A Proteins / Oncolytic Viruses / TNF-Related Apoptosis-Inducing Ligand Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2017 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peritoneal Neoplasms / Stomach Neoplasms / Adenovirus E1A Proteins / Oncolytic Viruses / TNF-Related Apoptosis-Inducing Ligand Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2017 Type: Article Affiliation country: China