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Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach.
Mendelson, Michael M; Marioni, Riccardo E; Joehanes, Roby; Liu, Chunyu; Hedman, Åsa K; Aslibekyan, Stella; Demerath, Ellen W; Guan, Weihua; Zhi, Degui; Yao, Chen; Huan, Tianxiao; Willinger, Christine; Chen, Brian; Courchesne, Paul; Multhaup, Michael; Irvin, Marguerite R; Cohain, Ariella; Schadt, Eric E; Grove, Megan L; Bressler, Jan; North, Kari; Sundström, Johan; Gustafsson, Stefan; Shah, Sonia; McRae, Allan F; Harris, Sarah E; Gibson, Jude; Redmond, Paul; Corley, Janie; Murphy, Lee; Starr, John M; Kleinbrink, Erica; Lipovich, Leonard; Visscher, Peter M; Wray, Naomi R; Krauss, Ronald M; Fallin, Daniele; Feinberg, Andrew; Absher, Devin M; Fornage, Myriam; Pankow, James S; Lind, Lars; Fox, Caroline; Ingelsson, Erik; Arnett, Donna K; Boerwinkle, Eric; Liang, Liming; Levy, Daniel; Deary, Ian J.
Affiliation
  • Mendelson MM; Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Marioni RE; Boston University School of Medicine, Boston, Massachusetts, United States of America.
  • Joehanes R; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, United States of America.
  • Liu C; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Hedman ÅK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
  • Aslibekyan S; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
  • Demerath EW; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Guan W; Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Zhi D; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Yao C; Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Huan T; Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Willinger C; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Chen B; Department of Biostatistics, Boston University, Boston, Massachusetts, United States of America.
  • Courchesne P; Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Multhaup M; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
  • Irvin MR; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
  • Cohain A; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
  • Schadt EE; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
  • Grove ML; Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Bressler J; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • North K; Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Sundström J; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Gustafsson S; Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Shah S; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • McRae AF; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Harris SE; Framingham Heart Study, Framingham, Massachusetts, United States of America.
  • Gibson J; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Redmond P; Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
  • Corley J; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
  • Murphy L; Icahn Institute for Genomics and Multiscale Biology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
  • Starr JM; Icahn Institute for Genomics and Multiscale Biology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
  • Kleinbrink E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
  • Lipovich L; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
  • Visscher PM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
  • Wray NR; Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Krauss RM; Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Fallin D; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Feinberg A; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Absher DM; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Fornage M; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  • Pankow JS; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
  • Lind L; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
  • Fox C; Wellcome Trust Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom.
  • Ingelsson E; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
  • Arnett DK; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
  • Boerwinkle E; Wellcome Trust Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom.
  • Liang L; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
  • Levy D; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom.
  • Deary IJ; Center for Molecular Medicine and Genetics and Department of Neurology, Wayne State University, Detroit, Michigan, United States of America.
PLoS Med ; 14(1): e1002215, 2017 Jan.
Article in En | MEDLINE | ID: mdl-28095459
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronary Artery Disease / Body Mass Index / Gene Expression Regulation / DNA Methylation / Lipid Metabolism / Leukocytes Type of study: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: PLoS Med Journal subject: MEDICINA Year: 2017 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronary Artery Disease / Body Mass Index / Gene Expression Regulation / DNA Methylation / Lipid Metabolism / Leukocytes Type of study: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: PLoS Med Journal subject: MEDICINA Year: 2017 Type: Article Affiliation country: United States