Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.

Bujisic, Bojan; De Gassart, Aude; Tallant, Rémy; Demaria, Olivier; Zaffalon, Léa; Chelbi, Sonia; Gilliet, Michel; Bertoni, Francesco; Martinon, Fabio

Bujisic, Bojan; De Gassart, Aude; Tallant, Rémy; Demaria, Olivier; Zaffalon, Léa; Chelbi, Sonia; Gilliet, Michel; Bertoni, Francesco; Martinon, Fabio.

Affiliation

Bujisic B; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
De Gassart A; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Tallant R; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Demaria O; Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Zaffalon L; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Chelbi S; Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Gilliet M; Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Bertoni F; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; and.
Martinon F; Lymphoma and Genomics Research Program, Institute of Oncology Research, Bellinzona, Switzerland.

Blood ; 129(17): 2420-2428, 2017 04 27.

Article in En | MEDLINE | ID: mdl-28167662

Subject(s)

B-Lymphocytes/immunology; Endoribonucleases/genetics; Gene Expression Regulation, Neoplastic; Germinal Center/immunology; Lymphoma, Large B-Cell, Diffuse/immunology; Protein Serine-Threonine Kinases/genetics; RNA, Messenger/genetics; X-Box Binding Protein 1/genetics; Animals; B-Lymphocytes/pathology; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Endoribonucleases/antagonists & inhibitors; Endoribonucleases/immunology; Enhancer of Zeste Homolog 2 Protein/antagonists & inhibitors; Enhancer of Zeste Homolog 2 Protein/genetics; Enhancer of Zeste Homolog 2 Protein/immunology; Epigenesis, Genetic; Germinal Center/pathology; Histones/genetics; Histones/immunology; Humans; Indazoles/pharmacology; Leupeptins/pharmacology; Lymphoma, Large B-Cell, Diffuse/genetics; Lymphoma, Large B-Cell, Diffuse/pathology; Lymphoma, Large B-Cell, Diffuse/therapy; Mice; Mice, 129 Strain; Plasma Cells/immunology; Plasma Cells/pathology; Promoter Regions, Genetic; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/immunology; Pyridones/pharmacology; RNA, Messenger/antagonists & inhibitors; RNA, Messenger/immunology; Signal Transduction; X-Box Binding Protein 1/antagonists & inhibitors; X-Box Binding Protein 1/immunology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / B-Lymphocytes / Gene Expression Regulation, Neoplastic / Lymphoma, Large B-Cell, Diffuse / Protein Serine-Threonine Kinases / Germinal Center / Endoribonucleases / X-Box Binding Protein 1 Type of study: Prognostic_studies Language: En Journal: Blood Year: 2017 Type: Article Affiliation country: Switzerland

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