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Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of ß-III spectrin and GLAST.
Perkins, Emma M; Suminaite, Daumante; Clarkson, Yvonne L; Lee, Sin Kwan; Lyndon, Alastair R; Rothstein, Jeffrey D; Wyllie, David J A; Tanaka, Kohichi; Jackson, Mandy.
Affiliation
  • Perkins EM; The Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK.
  • Suminaite D; The Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK.
  • Clarkson YL; The Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK.
  • Lee SK; The Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK.
  • Lyndon AR; School of Energy, Geoscience, Infrastructure and Society, Heriot-Watt University, John Muir Building, Riccarton, Edinburgh, UK.
  • Rothstein JD; Department of Neurology and Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Wyllie DJ; The Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK.
  • Tanaka K; Centre for Brain Development and Repair, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India
  • Jackson M; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-Ku, Tokyo, Japan.
Hum Mol Genet ; 25(20): 4448-4461, 2016 10 15.
Article in En | MEDLINE | ID: mdl-28173092
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purkinje Cells / Cerebellar Ataxia / Spectrin / Spinocerebellar Ataxias / Excitatory Amino Acid Transporter 1 / Disease Models, Animal / Excitatory Amino Acid Transporter 4 Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2016 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purkinje Cells / Cerebellar Ataxia / Spectrin / Spinocerebellar Ataxias / Excitatory Amino Acid Transporter 1 / Disease Models, Animal / Excitatory Amino Acid Transporter 4 Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2016 Type: Article Affiliation country: United kingdom