Role of PARP activity in lung cancer-induced cachexia: Effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype.

Chacon-Cabrera, Alba; Mateu-Jimenez, Mercè; Langohr, Klaus; Fermoselle, Clara; García-Arumí, Elena; Andreu, Antoni L; Yelamos, Jose; Barreiro, Esther

Chacon-Cabrera, Alba; Mateu-Jimenez, Mercè; Langohr, Klaus; Fermoselle, Clara; García-Arumí, Elena; Andreu, Antoni L; Yelamos, Jose; Barreiro, Esther.

Affiliation

Chacon-Cabrera A; Pulmonology Department-Lung Cancer and Muscle Research Group, IMIM-Hospital del Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Mateu-Jimenez M; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain.
Langohr K; Pulmonology Department-Lung Cancer and Muscle Research Group, IMIM-Hospital del Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Fermoselle C; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain.
García-Arumí E; Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, Hospital del Mal Medical Research Institute (IMIM), Barcelona, Spain.
Andreu AL; Department of Statistics and Operations Research, Universitat Politècnica de Barcelona/Barcelonatech, Barcelona, Spain.
Yelamos J; Pulmonology Department-Lung Cancer and Muscle Research Group, IMIM-Hospital del Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Barreiro E; Unitat de Patologia Neuromuscular i Mitocondrial, Hospital Universitari Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

J Cell Physiol ; 232(12): 3744-3761, 2017 Dec.

Article in En | MEDLINE | ID: mdl-28177129

Subject(s)

Cachexia/etiology; Lung Neoplasms/complications; Muscle Fibers, Skeletal/enzymology; Muscle Proteins/metabolism; Muscle, Skeletal/enzymology; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1/metabolism; Poly(ADP-ribose) Polymerases/metabolism; Proteolysis; Animals; Apoptosis; Biomarkers/metabolism; Cachexia/enzymology; Cachexia/genetics; Cachexia/pathology; Cell Line, Tumor; Diaphragm/enzymology; Diaphragm/pathology; Female; Genotype; Lung Neoplasms/enzymology; Lung Neoplasms/genetics; Lung Neoplasms/pathology; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Muscle/metabolism; Mitochondria, Muscle/pathology; Muscle Fibers, Skeletal/pathology; Muscle, Skeletal/pathology; NF-kappa B/metabolism; Organ Size; Phenotype; Poly (ADP-Ribose) Polymerase-1/deficiency; Poly (ADP-Ribose) Polymerase-1/genetics; Poly(ADP-ribose) Polymerases/deficiency; Poly(ADP-ribose) Polymerases/genetics; Proteasome Endopeptidase Complex/metabolism; Signal Transduction; Time Factors; Ubiquitination

Key words

PARP activity; Parp-1−/− and Parp-2−/− mice; cancer-induced cachexia; muscle anabolism and catabolism and mitochondrial content; muscle atrophy and myosin loss

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cachexia / Poly(ADP-ribose) Polymerases / Oxidative Stress / Muscle, Skeletal / Muscle Fibers, Skeletal / Proteolysis / Poly (ADP-Ribose) Polymerase-1 / Lung Neoplasms / Muscle Proteins Language: En Journal: J Cell Physiol Year: 2017 Type: Article Affiliation country: Spain

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