Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.

Xu, Wen Wen; Li, Bin; Guan, Xin Yuan; Chung, Sookja K; Wang, Yang; Yip, Yim Ling; Law, Simon Y K; Chan, Kin Tak; Lee, Nikki P Y; Chan, Kwok Wah; Xu, Li Yan; Li, En Min; Tsao, Sai Wah; He, Qing-Yu; Cheung, Annie L M

Xu, Wen Wen; Li, Bin; Guan, Xin Yuan; Chung, Sookja K; Wang, Yang; Yip, Yim Ling; Law, Simon Y K; Chan, Kin Tak; Lee, Nikki P Y; Chan, Kwok Wah; Xu, Li Yan; Li, En Min; Tsao, Sai Wah; He, Qing-Yu; Cheung, Annie L M.

Affiliation

Xu WW; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Li B; The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), Kejizhong 2nd Rd., Hi-Tech Industrial Park, Nanshan District, Shenzhen 518057, China.
Guan XY; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chung SK; The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), Kejizhong 2nd Rd., Hi-Tech Industrial Park, Nanshan District, Shenzhen 518057, China.
Wang Y; Centre for Cancer Research, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Yip YL; Centre for Cancer Research, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Law SY; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Chan KT; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Lee NP; College of Life Science and Technology, Jinan University, 601 West Huangpu Blvd., Guangzhou 510632, China.
Chan KW; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Xu LY; Centre for Cancer Research, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Li EM; Department of Surgery, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Tsao SW; Centre for Cancer Research, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
He QY; Department of Surgery, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Cheung AL; Centre for Cancer Research, Li Ka Shing Faculty of Medicine, 21 Sassoon Road, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

Nat Commun ; 8: 14399, 2017 02 10.

Article in En | MEDLINE | ID: mdl-28186102

Subject(s)

Bone Marrow Cells/metabolism; Cancer-Associated Fibroblasts/metabolism; Esophageal Neoplasms/metabolism; Insulin-Like Growth Factor II/metabolism; Stem Cells/metabolism; Animals; Cell Line, Tumor; Cells, Cultured; Disease Progression; Esophageal Neoplasms/genetics; Esophageal Neoplasms/pathology; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Differentiation Protein 1/genetics; Inhibitor of Differentiation Protein 1/metabolism; Insulin-Like Growth Factor II/genetics; Kaplan-Meier Estimate; Mice, Knockout; Mice, Nude; Transplantation, Heterologous; Vascular Endothelial Growth Factor A/blood; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Insulin-Like Growth Factor II / Bone Marrow Cells / Esophageal Neoplasms / Cancer-Associated Fibroblasts Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2017 Type: Article Affiliation country: China

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