The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses.

Jones, Jeremy C; Marathe, Bindumadhav M; Vogel, Peter; Gasser, Rodolfo; Najera, Isabel; Govorkova, Elena A

Jones, Jeremy C; Marathe, Bindumadhav M; Vogel, Peter; Gasser, Rodolfo; Najera, Isabel; Govorkova, Elena A.

Affiliation

Jones JC; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Marathe BM; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Vogel P; Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Gasser R; Roche Innovation Center, Basel, Switzerland.
Najera I; Roche Innovation Center, Basel, Switzerland.
Govorkova EA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA elena.govorkova@stjude.org.

Antimicrob Agents Chemother ; 61(5)2017 05.

Article in En | MEDLINE | ID: mdl-28193653

Subject(s)

Antiviral Agents/pharmacology; Endonucleases/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Guanine/analogs & derivatives; Influenza A virus/drug effects; Influenza B virus/drug effects; Orthomyxoviridae Infections/drug therapy; Animals; Antibiotic Prophylaxis; Cell Line; Dogs; Female; Guanine/pharmacology; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred BALB C; Post-Exposure Prophylaxis; Viral Load/drug effects; Virus Replication/drug effects

Key words

PA endonuclease; PA polymerase; antiviral; antiviral agents; influenza A virus; influenza B virus; mouse model

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Influenza A virus / Influenza B virus / Orthomyxoviridae Infections / Endonucleases / Enzyme Inhibitors / Guanine Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2017 Type: Article Affiliation country: United States

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