Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents.

van den Brink, Willem; Emerenciana, Annette; Bellanti, Francesco; Della Pasqua, Oscar; van der Laan, Jan Willem

van den Brink, Willem; Emerenciana, Annette; Bellanti, Francesco; Della Pasqua, Oscar; van der Laan, Jan Willem.

Affiliation

van den Brink W; Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Medicines Evaluation Board, Utrecht, The Netherlands.
Emerenciana A; Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Medicines Evaluation Board, Utrecht, The Netherlands.
Bellanti F; Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Della Pasqua O; Systems Pharmacology, Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Clinical Pharmacology Modelling & Simulation, GlaxoSmithKline, Stockley Park, Uxbridge, United Kingdom; Clinical Pharmacology & Therapeutics, UCL, School of L
van der Laan JW; Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Medicines Evaluation Board, Utrecht, The Netherlands. Electronic address: jw.vd.laan@cbg-meb.nl.

Toxicol Appl Pharmacol ; 320: 51-59, 2017 04 01.

Article in En | MEDLINE | ID: mdl-28213092

Subject(s)

Glucagon-Like Peptide-1 Receptor/agonists; Liraglutide/toxicity; Peptides/toxicity; Thyroid Neoplasms/chemically induced; Venoms/toxicity; Animals; Databases, Factual/trends; Drug Administration Schedule; Exenatide; Hypoglycemic Agents/administration & dosage; Hypoglycemic Agents/toxicity; Liraglutide/administration & dosage; Nonlinear Dynamics; Peptides/administration & dosage; Predictive Value of Tests; Rodentia; Thyroid Neoplasms/pathology; Venoms/administration & dosage

Key words

C-cell carcinogenicity; GLP-1r agonists; PKPD modelling; Pharmacology; Prediction

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Venoms / Thyroid Neoplasms / Liraglutide / Glucagon-Like Peptide-1 Receptor Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2017 Type: Article Affiliation country: Netherlands

Fulltext

XML

PubMed Links

Search on Google