Clinicopathologic characteristics of metastatic esophageal carcinoma isolated to the pineal region: A case report and review of the literature.
Exp Mol Pathol
; 102(2): 247-250, 2017 04.
Article
in En
| MEDLINE
| ID: mdl-28215583
ABSTRACT
Metastasis to the pineal region is a rare event, and esophageal adenocarcinoma metastatic to the pineal region is exceptionally rare, with only two cases reported in the current literature. Here, we characterize a third case of metastatic esophageal adenocarcinoma to the pineal region, and compare clinicopathological characteristics among all three cases. The three patients were men, with ages at neurological presentation ranging from 48 to 65years. Time from initial esophageal adenocarcinoma diagnosis to development of neurologic symptoms ranged from 12 to 23months. Neuroimaging in all cases showed an isolated enhancing pineal region mass with sizes ranging from 1.8 to 2.2cm. All cases were believed to have local control of esophageal disease prior to metastatic sequela, with initial treatment including esophageal resection with or without chemoradiation therapy. No cases had evidence of primary site disease progression at time of metastatic presentation, nor were there signs of other sites of metastasis. All patients underwent tumor excision and were referred for subsequent radiotherapy. Overall, all three cases demonstrate similar demographics, histology, and clinical presentations. In the appropriate clinical setting it is important to keep esophageal metastasis in the differential diagnosis, particularly in the setting of isolated pineal lesions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pineal Gland
/
Pinealoma
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Brain Neoplasms
/
Esophageal Neoplasms
/
Adenocarcinoma
Limits:
Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Exp Mol Pathol
Year:
2017
Type:
Article
Affiliation country:
United States