[Lipid-lowering effect of seven traditional Chinese medicine monomers in zebrafish system].
Sheng Li Xue Bao
; 69(1): 55-60, 2017 Feb 25.
Article
in Zh
| MEDLINE
| ID: mdl-28217808
ABSTRACT
The present study aimed to study lipid-lowering effect of seven traditional Chinese medicine monomers in zebrafish system. Zebrafish were fed with high fat diet to establish a hyperlipemia model, then fasted and bathed with seven traditional Chinese medicine monomers stigmasterol, triacontanol, chrysophanol, vanillic acid, shikimic acid, polydatin and oleanolic acid respectively. The oil red O staining was used to detect the blood lipids of zebrafish. Serum total cholesterol and triglyceride levels were detected to validate the lipid-lowering effect. The result showed that a zebrafish model of hyperlipemia could be established by feeding larvae zebrafish with high fat diet. Among the seven traditional Chinese medicine monomers, chrysophanol had lipid-lowering effect. Chrysophanol significantly reduced serum total cholesterol and triglyceride levels in adult zebrafish fed with high fat diet. Chrysophanol accelerated peristalsis frequency of zebrafish intestine and the excretion of high fat food. It is concluded that chrysophanol has lipid- lowering effect in zebrafish, and the mechanism of the effect may be due to the roles of chrysophanol in reducing lipid absorption from gastrointestinal tract and accelerating the excretion of food.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hyperlipidemias
/
Medicine, Chinese Traditional
/
Hypolipidemic Agents
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
Zh
Journal:
Sheng Li Xue Bao
Year:
2017
Type:
Article
Affiliation country:
China