Heterogeneous treatment effects in stratified clinical trials with time-to-event endpoints.

Beisel, Christina; Benner, Axel; Kunz, Christina; Kopp-Schneider, Annette

Beisel, Christina; Benner, Axel; Kunz, Christina; Kopp-Schneider, Annette.

Affiliation

Beisel C; Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.
Benner A; Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.
Kunz C; Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.
Kopp-Schneider A; Department of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.

Biom J ; 59(3): 511-530, 2017 May.

Article in En | MEDLINE | ID: mdl-28263395

Subject(s)

Biometry/methods; Clinical Trials as Topic/statistics & numerical data; Models, Statistical; Computer Simulation; Humans; Sample Size; Survival Analysis; Time Factors

Key words

Biomarkers; Cox proportional hazards model; Log-rank test; Sample size; Shared frailty model

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clinical Trials as Topic / Models, Statistical / Biometry Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biom J Year: 2017 Type: Article Affiliation country: Germany

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