HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy.

Krukowski, Karen; Ma, Jiacheng; Golonzhka, Olga; Laumet, Geoffroy O; Gutti, Tanuja; van Duzer, John H; Mazitschek, Ralph; Jarpe, Matthew B; Heijnen, Cobi J; Kavelaars, Annemieke

Krukowski, Karen; Ma, Jiacheng; Golonzhka, Olga; Laumet, Geoffroy O; Gutti, Tanuja; van Duzer, John H; Mazitschek, Ralph; Jarpe, Matthew B; Heijnen, Cobi J; Kavelaars, Annemieke.

Affiliation

Krukowski K; aDepartment of Symptom Research, Laboratory of Neuroimmunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA bAcetylon Pharmaceuticals Inc, Boston, MA, USA cCenter for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.

Pain ; 158(6): 1126-1137, 2017 06.

Article in En | MEDLINE | ID: mdl-28267067

Subject(s)

Cisplatin/adverse effects; Histone Deacetylase 6/antagonists & inhibitors; Hydroxamic Acids/administration & dosage; Pain/chemically induced; Pain/prevention & control; Peripheral Nervous System Diseases/chemically induced; Peripheral Nervous System Diseases/prevention & control; Pyrimidines/administration & dosage; Animals; Antineoplastic Agents/administration & dosage; Male; Mice; Mice, Inbred C57BL; Pain/diagnosis; Peripheral Nervous System Diseases/diagnosis; Rats; Rats, Sprague-Dawley; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Pyrimidines / Cisplatin / Peripheral Nervous System Diseases / Histone Deacetylase 6 / Hydroxamic Acids Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Pain Year: 2017 Type: Article Affiliation country: United States

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