Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein.

Boado, Ruben J; Pardridge, William M

Boado, Ruben J; Pardridge, William M.

Affiliation

Boado RJ; ArmaGen, Inc. , Calabasas, California 91302, United States.
Pardridge WM; ArmaGen, Inc. , Calabasas, California 91302, United States.

Mol Pharm ; 14(4): 1271-1277, 2017 04 03.

Article in En | MEDLINE | ID: mdl-28279069

Subject(s)

Antibodies, Monoclonal/metabolism; Antigens, CD/metabolism; Brain/metabolism; Iduronidase/metabolism; Receptor, Insulin/metabolism; Recombinant Fusion Proteins/metabolism; Animals; Blood-Brain Barrier/metabolism; Humans; Macaca mulatta; Mucopolysaccharidosis I/metabolism; Receptor, IGF Type 2/metabolism; Succinimides/metabolism

Key words

CSF; blood−brain barrier; drug delivery; iduronidase; insulin receptor; monoclonal antibody

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Brain / Receptor, Insulin / Antigens, CD / Iduronidase / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2017 Type: Article Affiliation country: United States

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